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Gray Cancer InstituteGray Cancer Institute
One way to do this is by introducing a therapeutic gene under the transcriptional control of a hypoxia regulatory element (HRE). HREs act as binding sites for an hypoxia-inducible transcription factor. This system of gene regulation, in response to low oxygen, has been demonstrated in all mammalian cells tested so far. We have shown that an HRE can control expression of a marker gene,...
http://www.graylab.ac.uk
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